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KMID : 0882420070730001101
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Korean Journal of Medicine
2007 Volume.73 No. 0 p.1101 ~ p.1105
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A case of minimal change nephropathy as a primary manifestation of dermatomyositis
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Seo Jun-Hyuk
Jo Min-Jae
You Jung-Hyun
Lee Dong-Wok
Kim Yong-Sup
Lee Chan-Woo
Oh Dong-Ho
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Abstract
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Dermatomyositis is a disease characterized by non-pyogenic inflammation of the skin and muscles in which the tissues and cells are damaged by pathogenic autoantibodies and immune complexes. Unlike interstitial lung disease, which is reported to occur in 15～30% of patients with dermatomyositis and polymyositis, renal lesions are rarely present with dermatomyositis and polymyositis. Only a few isolated cases of dermatomyositis associated glomerulonephritis have been reported to date. Therefore, we present a case of nephropathy as a primary manifestation of dermatomyositis. A 32-year-old female patient was admitted for renal biopsy due to facial edema and proteinuria. Renal biopsy showed the findings of minimal change nephropathy. Heliotroph rash and Gottron’s papules were noted on the physical examination. The findings of EMG, MRI of the thigh and thigh muscle biopsy were compatible with those of dermatomyositis. Minimal change nephropathy is a rare manifestation in patients with dermatomyositis, and we report this case with a review of literature.(Korean J Med 73:S1101-S1105, 2007)
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KEYWORD
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Dermatomyositis, Nephrotic syndrome
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